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Several cephalosporins have been implicated in triggering seizuresparticularly in patients with renal impairment when the dosage was not reducedsee DOSAGE AND ADMINISTRATION and OVERDOSAGEIf seizures associated with drug therapy occurthe drug should be discontinuedAnticonvulsant therapy can be given if clinically indicated.
May potentiate carbamazepineanticoagulantsegwarfarinmonitorMay cause falseClinitestdirect Coomb’snitroprusside test for ketonesPotentiated by probenecid.
Cefdinir and cefiximeSupraxare 3rd generation cephalosporin antibiotics used to treat a wide range of infectionsfor exampleMiddle ear infections Tonsillitis Strep Throat Laryngitis Sinusitis Bronchitis Pneumonia Skin and soft tissue infections Cefdinir and cefixime have similar side effects that includeDiarrhea Nausea Vomiting Abdominal pain Headache Vaginitis Skin rash Rarelyabnormal liver tests Side effects of cefdinir that are different from cefixime include vaginal yeast infectionRare side effects of cefdinir includeChanges is stool color or consistency Constipation Dry mouth Side effects of cefixime that are different from cefdinir includeFever Joint pain Arthritis Itching Dizziness Both cefdinir and cefixime may cause a potentially serious condition called pseudomembranous colitisClostridium difficile colitisCdiffa bacterial infection of the colonIf you are allergic to penicillin-type antibioticsyou also may be allergic to cefdinir or cefiximeRarebut serious allergic reactions to cefdinir and cefixime includeSeizures Anaphylaxissevere allergic reactionsLow red blood cell or platelet countsThe brand name for cefdinir called Omnicef has been discontinued in the U.S.
Alternative treatment of uncomplicated urogenitalanorectalor pharyngeal gonorrhea if ceftriaxone unavailableno longer indicated as first-line treatmentper CDC guidelines.
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